Mild-intensity Exercise Triggers VEGF in the Digestive Tract Via Both Hypoxic and Nonhypoxic Mechanisms

• DOI: 10.1590/1678-4324-2020200059
• Publication Date: 2020-08-10T23:56:04Z
• Authors: Ferda Hosgorler; Servet Kizildag; Basar Koc; Oguz Yüksel; Ayse Birsu Topcug...; Rabia Ilgin; Sevim Kandis; Güven Güvendi; Mehmet Ates; Nazan Uysal
• Keywords: 0301 basic medicine; 03 medical and health sciences; exercise; hypoxia; gastrointestinal; VEGF; TP248.13-248.65; Biotechnology; 3. Good health

Hypoxia occurs in the splanchnic region during exercise associated with sympathetic activity.In elderly, vascular insufficiency and low endothelial growth factor (VEGF) expression are observed.Compared to young people, signals of older individuals blunted more resistant blood flow alterations exercise.VEGF induces vasodilation responses hence may retain bed.We hypothesized that regular mild-intensity triggers weak VEGF digestive tract elderly.The effects on levels VEGF, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) total antioxidant capacity (T-AOC) stomach, jejunum, ileum colon tissues were evaluated.With exercise, stomach increased.Although SOD, GPx, MDA decreased HIGHLIGHTS  Low is observed elderly. Exercise leads hypoxia region. Mild intensity In subjects, mild increases stomach. Hypoxic involvement due pronounced large intestine compared other parts tract. Insert 1-4 highlights no longer than 85 characters. a highlight characters.• characters.