Characterizations of alveolar repair after mandibular second molar extraction: an experimental study in rats

• DOI: 10.1590/1678-7757-2022-0010
• Publication Date: 2022-07-08T12:20:59Z
• Authors: Jianbin Li; Zhenxian Sheng; Jing Sun; Ronglin Wang; Xijiao Yu
• Keywords: Alveolar ridge; Masson's trichrome stain; Mandible (arthropod mouthpart)

Characterizations of rat mandibular second molar extraction socket with significantly different buccal and lingual alveolar ridge width remain unclear.To observe alterations in the after molars, to examine processes healing an experimental model absorption preservation.Eighteen Wistar rats were included divided into six groups regarding time study. Bilateral molars extracted. The tooth sockets took 0, 1.5, 2, 3, 4 8 weeks healing. Histological observation, tartrate-resistant acidic phosphatase (TRAP) staining, Masson's trichrome immunohistochemical staining micro-computed tomography (micro-CT) applied estimate ridge.Different led height loss. Lingual wall (LH) decreased two extraction. Buccal rarely reduced its higher width. From eight extraction, bone volume (BV/TV), density (BMD), trabecular thickness (Tb.Th) progressively increased socket, which gradually Tb.Sp Tb.N. LH showed no significant change during same period. Osteogenic marker OCN OPN repair from weeks. was repaired later stage. Osteoclast activity within operation. We observed positive expression EMMPRIN MMP-9 osteoclasts that participated spire region.Extraction may help study preservation. EMMPRIN-MMP-9 pathway be a candidate for further on attenuating resorption