Collared Pecary (tayassu tajacu) as a new model of renal ischemic injury induced by clamping the renal artery

• DOI: 10.1590/s0102-8650201400150003
• Publication Date: 2014-09-17T18:54:14Z
• Authors: Dayseanny de Oliv...; Matheus Levi Tajr...; Hatawa Melo de Al...; Francisco Assis L...; Juliana Fortes Vi...; Francisco de Assi...; Flávio Ribeiro Alves; Gerson Tavares Pe...; Maria Acelina Mar...
• Keywords: Renal Injury

PURPOSE: The use of the collared peccary as an experimental model for ischemic nephropathy. METHODS: A total 12 (Tayassu tajacu) was used and nephropathy induced in six these animals that constituted group (G1) while other formed control (G2). Ischemic surgically by partial occlusion left renal artery. disease course assessed hematological tests, serum chemistry, urinalysis, ultrasound (US) doppler function artery before induction, at five, 10, 15 20 days after surgery. Twenty occlusion, unilateral nephrectomy histopathological examination were performed to assess morphology. RESULTS: Statistical analysis Fischer's test showed a significant difference (p<0.05) between group. glomerular, tubular interstitial lesions. In group, 83.3% (5 /6) moderate lesions only 16.7% (1/6) classified with no right kidney presented statistical day 5 10 post occlusion. CONCLUSION: good disease, because it could be manipulated during research time without death, health conditions permit any subsequent procedure therapy.