Grape seed protects cholestatic rats liver from ischemia/reperfusion injury

• DOI: 10.1590/s0102-865020160030000006
• Publication Date: 2017-03-15T17:46:44Z
• Authors: Tuğrul Çakır; Arif Aslaner; Seçkin Özgür Tekeli; Kasım Güneş; Erdem Kinaci; Uğur Doğan; Feyza Tekeli; Cebrail Akyüz; Süleyman Koç; Necat Yılmaz
• Keywords: Malondialdehyde; Histopathological examination

PURPOSE: To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS: Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, subjected to 30 min hepatic ischemia, followed 60 reperfusion. Oral administration 50 mg/kg/day started 15 before ligation continued second operation group. Serum, plasma liver samples taken. Laboratory analysis, tissue gluthation, malondialdehyde, myeloperoxidase levels histopathological examination performed. RESULTS: Significant decrease gluthation level significant increase malondialdehyde activity observed after rats. Serum for laboratory analysis also significantly higher I/R Hepatic necrosis fibrosis detected examination. administiration reversed all these parameters findings except serum bilirubin levels. CONCLUSION: treatment can improve functions attenuate inflammation oxidative stress injury.