An experimental study of ascorbic acid effects in acute renal failure under general anesthesia

• DOI: 10.1590/s0102-865020170100000007
• Publication Date: 2017-11-11T22:43:03Z
• Authors: Omur Ozturk; Sefer Ustebay; Huseyin Avni Eroglu; Murat Günay; Yasemen Adali; İlksen Donmez; Mesut Erbas
• Keywords: Blood urea nitrogen

Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects allocated 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) high (300 doses AA addition to sevoflurane, respectively. Rhabdomyolysis myohemoglobinuric ARF was formed by intramuscular administration glycerol upper hind limb 15th minute inhalation anesthesia. Biochemical parameters consisted serum levels blood urea nitrogen, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), total antioxidant capacity (TAC), protein carbonyl content. Histopathological variables tubular necrosis, fibrin, cast formation. Results: NGAL significantly lower than I. On other hand, TAC, PCO, creatinine notably higher compared with III. There a significant difference between groups frequencies necrosis (p=0.003), fibrin (p<0.001) (p<0.001). Acute formation more prominent Casts common Conclusions: The serve as prophylactic agent against damage patients receiving anesthesia associated apparent protective effects.