Randomized, Multicenter Comparison of Oral Granisetron and Oral Ondansetron for Emetogenic Chemotherapy
Adult
Aged, 80 and over
Male
Administration, Oral
Antineoplastic Agents
Nausea
Middle Aged
Ondansetron
Dexamethasone
Granisetron
3. Good health
03 medical and health sciences
0302 clinical medicine
Humans
Drug Therapy, Combination
Female
Emetics
Aged
DOI:
10.1592/phco.20.17.1318.34894
Publication Date:
2004-06-15T19:27:47Z
AUTHORS (6)
ABSTRACT
Study Objectives. To compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those of oral ondansetron plus dexamethasone administered before emetogenic chemotherapy.Design. Randomized, prospective, multicenter, open‐label study.Settings. University‐teaching hospital and veterans health care system.Patients. Sixty‐one chemotherapy‐naïve patients scheduled to receive emetogenic antineoplastic agents.Intervention. A single‐dose oral granisetron 1 mg and dexamethasone 12 mg or single‐dose oral ondansetron 16 mg and dexamethasone 12 mg was administered before chemotherapy.Measurements and Results. Twenty‐four hours after administration patients were contacted to assess nausea, emesis, and adverse events. There were no statistical differences in frequency of nausea or emesis between groups. Seventy‐six percent and 82% of patients receiving ondansetron and granisetron, respectively, experienced no emesis 24 hours after chemotherapy. Complete protection from nausea occurred in 58% and 46% of patients receiving the drugs, respectively. Adverse events were similar between groups.Conclusion. Oral granisetron 1 mg and ondansetron 16 mg plus dexamethasone are safe and effective in preventing nausea and vomiting related to emetogenic chemotherapy.
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