Randomized, Multicenter Comparison of Oral Granisetron and Oral Ondansetron for Emetogenic Chemotherapy

• DOI: 10.1592/phco.20.17.1318.34894
• Publication Date: 2004-06-15T19:27:47Z
• Authors: Jon D. Herrington; Peter Kwan; Robyn R. Young; Elaine Lagow; Lore Lagrone; Mark W. Riggs
• Keywords: Ondansetron; Granisetron

Study Objectives. To compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those ondansetron administered before emetogenic chemotherapy. Design. Randomized, prospective, multicenter, open‐label study. Settings. University‐teaching hospital veterans health care system. Patients. Sixty‐one chemotherapy‐naïve patients scheduled to receive antineoplastic agents. Intervention. A single‐dose 1 mg 12 or 16 was Measurements Results. Twenty‐four hours after administration were contacted assess nausea, emesis, adverse events. There no statistical differences in frequency nausea emesis between groups. Seventy‐six percent 82% receiving granisetron, respectively, experienced 24 Complete protection from occurred 58% 46% drugs, respectively. Adverse events similar Conclusion. Oral are safe effective preventing vomiting related