Rapid Development of Acinetobacter baumannii Resistance to Tigecycline

• DOI: 10.1592/phco.27.8.1198
• Publication Date: 2007-07-27T13:57:57Z
• Authors: Gail E. Reid; Shellee A. Grim; Christine A. Aldeza; William M. Janda; Nina M. Clark
• Keywords: Tigecycline; Acinetobacter baumannii; Sputum culture

A 53-year-old woman experienced a multidrug-resistant (MDR) Acinetobacter baumannii urinary tract infection 5 months after undergoing kidney and liver transplantation. The tigecycline minimum inhibitory concentration (MIC) for her A. isolate was 1.5 microg/ml; the patient received 2 weeks of therapy with intravenous as 100-mg loading dose followed by 50 mg every 12 hours, no lapses in treatment resolution infection. Three later, MDR isolated from sputum setting clinical evidence pneumonia, restarted; MIC microg/ml. At approximately same time, found to have paraspinal abscess spinal osteomyelitis. Cultures fluid grew 24 follow-up culture again yielded baumannii, but Urine at that time also Clinicians should be aware MICs isolates may increase during only brief exposure drug. Patients receiving monitored development resistance, microbiologic resistance.