Association between Renal Tubular Dysfunction and Mortality among Residents in a Cadmium-Polluted Area, Nagasaki, Japan.

• DOI: 10.1620/tjem.164.93
• Publication Date: 2008-03-12T05:21:47Z
• Authors: KOKICHI IWATA; HIROSHI SAITO; MASAKI MORIYAMA; ATSUHIRO NAKANO
• Keywords: CADMIUM EXPOSURE; Cadmium poisoning

IWATA, K., SAITO, H., MORIYAMA, M. and NAKANO, A. Association between Renal Tubular Dysfunction Mortality among Residents in a Cadmium-Polluted Area, Nagasaki, Japan. Tohoku J. Exp. Med., 1991, 164 (2), 93-102- A retrospective cohort study was carried out to clarify the effect of exposure environmental cadmium (Cd) on mortality. total 256 residents aged 50 years or older, living Sasu, Cd-polluted area Tsushima Island Nagasaki Prefecture, Japan, were followed from July 1979 February 1989. The expected number deaths calculated based sex- age- specific mortality rate 1985. In Sasu both sexes with urinary β2-microglobulin (β2-m) concentration greater than 1, 000μg/g creatinine 1979, observed expected. However, p value difference less 0.05 only men. relationships age, mean blood pressure, β2-m Cd examined using Cox's proportional hazards model. Urinary independently significantly related men but not women. results suggest an association Cd-induced renal tubular dysfunction