Postprandial Glucose Surges after Extremely Low Carbohydrate Diet in Healthy Adults

• DOI: 10.1620/tjem.243.35
• Publication Date: 2017-09-14T22:22:56Z
• Authors: Koji Kanamori; Noriko Ihana-Sugi...; Ritsuko Yamamoto-...; Tomoka Nakamura; Chie Sobe; Shigemi Kamiya; Miyako Kishimoto; Hiroshi Kajio; Kimiko Kawano; Mitsuhiko Noda
• Keywords: Korean population

Carbohydrate-restricted diets are prevalent not only in obese people but also the general population to maintain appropriate body weight. Here, we report that extreme carbohydrate restriction for one day affects subsequent blood glucose levels healthy adults. Ten subjects (median age 30.5 years, BMI 21.1 kg/m2, and HbA1c 5.5%), wearing with a continuous monitoring device, were given isoenergetic test meals 4 consecutive days. On 1, 2 (D2), (D4), they consumed normal-carbohydrate (63-66% carbohydrate) diet, while on 3, took low-carbohydrate/high-fat (5% diet. The daily energy intake was 2,200 kcal males 1,700 females. D2 D4, calculated mean 24-hr level (MEAN/24h) its standard deviation (SD/24h), area under curve (AUC) over 140 mg/dL within hours after each meal (AUC/4h/140), amplitude of glycemic excursions (MAGE), incremental AUC above plus (iAUC/MEAN+SD). Indexes fluctuation D4 significantly greater than those (SD/24h; p = 0.009, MAGE; 0.013, AUC/4h/140 breakfast dinner; 0.006 0.005, iAUC/MEAN+SD; 0.007). value MEAN/24h lunch D2, differences statistically significant. In conclusion, consumption diet appears cause higher postprandial particularly dinner