Resident Endothelial Precursors in Muscle, Adipose, and Dermis Contribute to Postnatal Vasculogenesis

• DOI: 10.1634/stemcells.2006-0795
• Publication Date: 2007-09-07T00:48:48Z
• Authors: Guillaume Grenier; Anthony Scimè; Fabien Le Grand; Atsushi Asakura; Carolina Perez-Ir...; Miguel A. Andrade...; Patricia A. Labosky; Michael A. Rudnicki
• Keywords: Vasculogenesis; CD31

Abstract A novel population of tissue-resident endothelial precursors (TEPs) was isolated from small blood vessels in dermal, adipose, and skeletal muscle mouse based on their ability to be grown as spheres. Cellular molecular analyses these cells revealed that they were highly related regardless the tissue origin distinct embryonic neural stem cells. Notably, TEPs did not express hematopoietic markers, but expressed numerous characteristics angiogenic differentiated progeny, such CD34, Flk-1, Tie-1, CD31, vascular cadherin (VE-cadherin). readily into newly formed networks following transplantation regenerating muscle. Taken together, experiments suggest represent a class are closely associated with muscle, dermal tissue. This finding is particular interest since it could bring new insight cancer angiogenesis collateral developed ischemia. Disclosure potential conflicts found at end this article.