Periodontal Ligament Stem Cell-Mediated Treatment for Periodontitis in Miniature Swine

• DOI: 10.1634/stemcells.2007-0734
• Publication Date: 2008-02-01T01:45:40Z
• Authors: Yi Liu; Ying Zheng; Gang Ding; Dianji Fang; Chunmei Zhang; Peter Mark Bartold; Stan Gronthos; Songtao Shi; Songlin Wang
• Keywords: Periodontal fiber

Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke, diabetes. At present, there no ideal therapeutic approach cure periodontitis achieve optimal regeneration. In this study, we explored potential of using autologous ligament stem cells (PDLSCs) treat defects porcine model periodontitis. The lesion was generated first molars area miniature pigs by surgical removal bone subsequent silk suture around cervical portion tooth. Autologous PDLSCs were obtained from extracted teeth then expanded ex vivo enrich PDLSC numbers. When transplanted into surgically created defect areas, capable regenerating tissues, leading favorable treatment This study demonstrates feasibility cell-mediated engineering diseases.