Exposure to 5 cGy 28Si Particles Induces Long-Term Microglial Activation in the Striatum and Subventricular Zone and Concomitant Neurogenic Suppression

• DOI: 10.1667/rade-21-00021.1
• Publication Date: 2022-04-04T14:19:21Z
• Authors: Son T. Ton; Julia R. Laghi; Shih-Yen Tsai; Ashley A. Blackwell; Natalie S. Adamczyk; Jenna R. Osterlun...; Richard A. Britten; Douglas G. Wallace; Gwendolyn L. Kartje
• Keywords: Doublecortin

The proposed mission to Mars will expose astronauts space radiation that is known adversely affect cognition and tasks rely on fine sensorimotor function. Space has also been shown the microglial neurogenic responses in central nervous system (CNS). We recently reported a low dose of 5 cGy 600 MeV/n 28Si results impaired skilled motor behavior adult rats. Since these at least part proper functioning striatum, we examined striatal cells same subjects. Using morphometric analysis, found exposure increased activated striatum. majority Iba1+ microglia were ED1–, indicating they an alternatively state, where do not have phagocytic activity but may be releasing cytokines could negatively impact neuronal In other areas studied, subventricular zone (SVZ), dentate gyrus (DG). Additionally, relationship between response neurogenesis. An analysis new neurons DG revealed increase doublecortin-positive (DCX+) hilar ectopic granule (hEGC) which correlated with cells, suggesting contributed this aberrant distribution hippocampal Taken together, indicate single persistent cellular effects CNS both short long-term following deep missions.