Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.

• DOI: 10.1667/rr14784.1
• Publication Date: 2017-05-10T16:23:38Z
• Authors: Deborah E. Citrin; Pataje G. S. Pras...; Amanda J. Walker; Michael L. Freeman; Iris Eke; Mary Helen Barcel...; Molykutty J. Aran...; Eric P. Cohen; Ruth C. Wilkins; Mansoor M. Ahmed; Mitchell S. Anscher; Benjamin Movsas; Jeffrey C. Buchsbaum; Marc S. Mendonca; Thomas A. Wynn; C. Norman Coleman
• Keywords: Epidemiology; Pulmonary Fibrosis; Oncology and Carcinogenesis; Medical and Health Sciences; Vaccine Related; 03 medical and health sciences; Rare Diseases; 0302 clinical medicine; Theoretical and computational chemistry; Humans; Oncology & Carcinogenesis; Cancer; Evidence-Based Medicine; Biomedical and Clinical Sciences; Radiotherapy; Prevention; Oncology and carcinogenesis; Biological Sciences; National Cancer Institute (U.S.); United States; 3. Good health; Radiation Pneumonitis; Treatment Outcome; Physical Sciences

A workshop entitled “Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate” (held in Rockville, MD, September 19, 2016) was organized by the Radiation Research Program and Radiation Oncology Branch of the Center for Cancer Research (CCR) of the National Cancer Institute (NCI), to identify critical research areas and directions that will advance the understanding of radiation-induced fibrosis (RIF) and accelerate the development of strategies to mitigate or treat it. Experts in radiation biology, radiation oncology and related fields met to identify and prioritize the key areas for future research and clinical translation. The consensus was that several known and newly identified targets can prevent or mitigate RIF in pre-clinical models. Further, basic and translational research and focused clinical trials are needed to identify optimal agents and strategies for therapeutic use. It was felt that optimally designed preclinical models are needed to better study biomarkers that predict for dev...