Cell Survival Fraction Estimation Based on the Probability Densities of Domain and Cell Nucleus Specific Energies Using Improved Microdosimetric Kinetic Models

• DOI: 10.1667/rr2842.1
• Publication Date: 2012-10-01T16:48:52Z
• Authors: Tatsuhiko Sato; Yoshiya Furusawa
• Keywords: Stochastic modelling

Estimation of the survival fractions cells irradiated with various particles over a wide linear energy transfer (LET) range is great importance in treatment planning charged-particle therapy. Two computational models were developed for estimating based on concept microdosimetric kinetic model. They designated as double-stochastic and stochastic models. The former model takes into account natures both domain cell nucleus specific energies, whereas latter represents nature by its approximated mean value variance to reduce time. probability densities energies are fundamental quantities expressing these These calculated using LET-estimator functions implemented Particle Heavy Ion Transport code System (PHITS) combination convolution or database method. Both can reproduce measured high-LET high-dose irradiations, previously proposed predicts lower values fractions, mainly due intrinsic ignorance calculation. we should contribute better understanding mechanism inactivation, well improve accuracy