A New Approach to Evaluate the Total Reserve of Hematopoietic Progenitors after Acute Irradiation

• DOI: 10.1667/rr3225
• Publication Date: 2006-07-17T20:03:27Z
• Authors: Teresa Grande; Juan A. Bueren
• Keywords: Progenitor

Grande, T. and Bueren, J. A. A New Approach to Evaluate the Total Reserve of Hematopoietic Progenitors after Acute Irradiation. Radiat. Res. 162, 397–404 (2004).Based on capacity certain hematopoietic growth factors mobilize progenitors from bone marrow peripheral blood, we have investigated whether number that can be mobilized blood irradiation correlates with radiation dose reflects total reserve survive exposure. In three different mouse strains, a close relationship was observed between G-CSF received by animals. When replaced one single injection SD01 plus thrombopoietin, similar two parameters observed, which fitted multitarget theoretical model. This treatment also promoted 50% survival in mice receiving lethal 9 Gy. The estimation CFU-GM irradiated allowed us establish good were respect global surviving progenitors. These results suggest quantification would predict severity reversibility syndrome victims, based direct estimations their stem cells.