Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells

• DOI: 10.1677/jme.0.0320497
• Publication Date: 2004-12-02T23:43:59Z
• Authors: WM Cao; K Murao; H Imachi; C Hiramine; H Abe; X Yu; H Dobashi; NC Wong; J Takahara; T Ishida
• Keywords: Scavenger Receptor

The thymus contains many apoptotic cells that arise from the process of positive and negative selection. Both thymic macrophages nurse cells/nursing epithelial (nursing TECs), non-professional phagocytes, recognize ingest without inflammation or tissue damage. Previously we reported human scavenger receptor class B (SR-B1) is involved in recognition thymocytes by nursing TECs. In this study, examined expression role a phosphatidylserine (PSR). This believed to participate clearance cells. PSR was strongly expressed Transforming growth factor-beta augmented leading enhanced binding TECs, suppressed SR-B1 with anti-PSR antibody decreased Our results suggest both are TECs these receptors appear play major thymus.