Systemic administration of oxytocin reduces basal and lipopolysaccharide-induced ghrelin levels in healthy men

• DOI: 10.1677/joe-09-0227
• Publication Date: 2009-07-09T01:57:32Z
• Authors: Greisa Vila; Michaela Riedl; Michael Resl; Aart Jan van der ...; Leo J Hofland; Martin Clodi; Anton Luger
• Keywords: Energy homeostasis

Oxytocin (OXT) and ghrelin have several common properties such as the involvement in first phase response to stressors, appetite regulation, modulation of neural functions. Despite a recent study showing that intraventricular administration activates OXT neurons, little is known on cross-talk between these two peptides. Here, we investigated role i.v. circulating concentrations under fasting conditions during lipopolysaccharide (LPS)-induced endotoxemia. A randomized placebo-controlled cross-over was performed ten healthy men. In four sessions, participants received once placebo, (1 pmol/kg per min over 90 min), LPS (2 ng/kg), both LPS. Plasma ghrelin, glucose, free fatty acid (FFA) levels were measured at regular intervals 6 h following bolus. Systemic decreased within 1 plasma (611+/-54 vs 697+/-52 pg/ml placebo days, P=0.013) increased glucose FFA (P=0.002 P=0.005 respectively). also reduced LPS-induced surge time point 2 (P=0.021). summary, decreases fasting, well endotoxemia The might be important regulation energy homeostasis stress responses.