Pulsatile LH secretion in streptozotocin-induced diabetes in the rat

• DOI: 10.1677/joe.0.1310049
• Publication Date: 2008-12-11T23:11:20Z
• Authors: Q. Dong; R. M. Lazarus; L. S. Wong; M. Vellios; D. J. Handelsman
• Keywords: Pulsatile flow

ABSTRACT This study aimed to determine the effect of streptozotocin (STZ)-induced diabetes on pulsatile LH secretion in mature male rat. pulse frequency was reduced by 56% and amplitude 54%, with a consequential decrease 72% mean levels 8 days after i.v. administration STZ (55 mg/kg) castrated Wistar rats compared non-diabetic controls. Twice daily insulin treatment completely reversed all parameters control values. Food-restricted controls, studied distinguish metabolic from that concurrent weight loss, demonstrated 34% reduction but no significant changes or controls given free access food. To whether decreased due either quantity hypothalamic gonadotrophin-releasing hormone (GnRH) released per secretory episode pituitary responsiveness GnRH, exogenous GnRH (1–1000 ng/kg body weight) tested diabetic castration, using full Latin square experimental design. The net response (total area under curve over 40 min following GnRH) 33% ( P =0·001) rats. STZ-induced therefore suggests is decelerate directly firing rate generator independent testicular feed-back. These effects were fully only partly associated loss. impaired at least involved amplitude. Journal Endocrinology (1991) 131, 49–55