Type 1 angiotensin II receptors in rat and human sperm

• DOI: 10.1677/joe.0.1440369
• Publication Date: 2008-12-11T22:39:29Z
• Authors: G P Vinson; J R Puddefoot; M M Ho; S Barker; J Mehta; E Saridogan; O Djahanbakhch
• Keywords: Spermatid

The physiological factors which induce and maintain mammalian sperm maturation motility generally remain unclear, although several agents are known to be involved. We describe here the application of immunocytochemical immunoblotting methods identify angiotensin II type 1 (AT1) receptor in tails ejaculated rat human sperm. Motility data on stimulated unstimulated from volunteers patients attending fertility clinics showed that may increase both percentage motile their linear velocity, while specific AT1 antagonist DuP753 inhibited action In seminiferous tubules, receptors were present primary spermatogonia spermatid tails, but immunoreactivity was not seen contained caput or cauda epididymis, showing function is regulated during transit through reproductive tract. Since local tissue reninangiotensin systems male female tracts, suggest has a role maintenance fertility.