Involvement of IGF-II in human cancer

• DOI: 10.1677/joe.0.1490367
• Publication Date: 2004-12-02T23:42:13Z
• Authors: J A Toretsky; L J Helman
• Keywords: Transcriptional Activation; 0303 health sciences; Transcription, Genetic; Cell Membrane; Receptor, IGF Type 2; 3. Good health; Insulin-Like Growth Factor Binding Proteins; Genomic Imprinting; 03 medical and health sciences; Insulin-Like Growth Factor II; Neoplasms; Humans; Signal Transduction

Introduction Insulin-like growth factor-II (IGF-II) is a regulatory peptide which critical for normal organismal and differentiation, implicated in tumor progression metastasis by variety of mechanisms, many otherwise unrelated tumors. IGF-II signaling pathways involve two specific receptors. A family six unique binding proteins exist, as well protein proteases which, turn, regulate IGF-II-binding levels. This report briefly describes the structural functional characteristics molecule discusses various mechanisms overactivity leading to growth. Wilms' tumor, rhabdomyosarcoma, neuroblastoma illustrate involvement metastasis. In tumors where thought play role pathogenesis, pathway may serve potential therapeutic target. Components overexpression The gene human found on short