Estrogen receptor specificity for the effects of estrogen in ovariectomized mice

• DOI: 10.1677/joe.0.1740167
• Publication Date: 2004-12-02T23:42:13Z
• Authors: MK Lindberg; Z Weihua; N Andersson; S Moverare; H Gao; O Vidal; M Erlandsson; S Windahl; G Andersson; DB Lubahn; H Carlsten; K Dahlman-Wright; JA Gustafsson; C Ohlsson
• Keywords: Estrogen receptor alpha; Estrogen receptor beta

Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both receptors, were given subcutaneously (2.3 micro g/mouse per day) effects on different estrogen-responsive parameters, including skeletal studied. We found that increased cortical bone dimensions in wild-type (WT) double ER knockout (DERKO) mice. DNA microarray analysis was performed characterize this effect it identified four genes regulated by WT DERKO The mice might either due remaining ERalpha activity represent an ERalpha/ERbeta-independent effect. Other estrogen, such as trabecular mineral density, thymic atrophy, fat reduction uterine weight, mainly mediated.