Rapid nongenomic effects of glucocorticoids on allergic asthma reaction in the guinea pig

• DOI: 10.1677/joe.0.177r001
• Publication Date: 2004-12-02T23:42:13Z
• Authors: J Zhou; ZM Kang; QM Xie; C Liu; SJ Lou; YZ Chen; CL Jiang
• Keywords: Male; 0303 health sciences; Time Factors; Guinea Pigs; Asthma; 3. Good health; 03 medical and health sciences; Administration, Inhalation; Models, Animal; Hypersensitivity; Animals; Budesonide; Glucocorticoids

Glucocorticoids (GCs) are routinely believed to work solely through genomic mechanisms. Recent evidence indicates that GCs can act at the membrane exert rapid nongenomic effects on various tissues and cells. To ascertain whether of exist allergic asthma reaction, Hartley guinea pigs were sensitized with ovalbumin challenged same antigen given by aerosol. Some animals received inhaled budesonide (3 mg/ml suspended in Hydroxypropyl methylcellulose vehicle) for 5 minutes before challenge; Other saline or blank vehicle as control. We measured changes lung resistance dynamic compliance, pulmonary function used evaluate severity. Inhaled inhibited reaction within 10 minutes, which would preclude genomic-mediated responses normally takes several hours occur. This study infers first time effect exists provides a new way investigate mechanism GCs. Further raise possibility therapeutic strategies disease including asthma.