The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice

• DOI: 10.1677/joe.1.06630
• Publication Date: 2006-05-26T18:49:26Z
• Authors: Hu Huang; Kaoruko Tada Iida; Hirohito Sone; Tomotaka Yokoo; Nobuhiro Yamada; Ryuichi Ajisaka
• Keywords: Adiponectin receptor 1

Adiponectin is an adipocyte-derived factor that plays a pivotal role in lipid and glucose metabolism. Recently, two types of adiponectin receptors (AdipoR1 AdipoR2) were identified. We investigated whether exercise training (ET) or dietary restriction (DR) affects the expression skeletal muscle liver, thereby improving metabolism KKAy mice. mice subjected to 8 weeks food restriction. Following experimental protocol, intravenous tolerance test intraperitoneal insulin performed addition measurement blood concentrations. The mRNA levels adiponectin, genes are putatively regulated by also analyzed. Both 8-week protocol improved resistance but did not alter plasma concentration nor its expression. In comparison with C57BL/6 mice, AdipoR1 level was significantly decreased AdipoR2 increased liver After approximately 1.8-fold greater 1.3-fold 30% less ET group as compared control group. Additionally, group, acyl coenzyme A-oxidase carnitine palmitoyl transferase 1 (CPT1) muscle. contrast, no significant changes observed encoding other except for CPT1 DR These findings suggest chronic