Cyclooxygenase 2 Promotes Parathyroid Hyperplasia in ESRD

• DOI: 10.1681/asn.2010060594
• Publication Date: 2011-02-19T04:13:15Z
• Authors: Qian Zhang; Junsi Qiu; Haiming Li; Yanwen Lu; Xiaoyun Wang; Junwei Yang; Shaoqing Wang; Liyin Zhang; Yong Gu; Chuan-Ming Hao; Jing Chen
• Keywords: Parathyroid chief cell; Uremia; Parathyroid gland; Pathogenesis

Hyperplasia of the PTG underlies secondary hyperparathyroidism (SHPT) observed in CKD, but mechanism underlying this hyperplasia is incompletely understood. Because aberrant cyclooxygenase 2 (COX2) expression promotes epithelial cell proliferation, we examined effects COX2 on parathyroid gland uremia. In patients with ESRD who underwent parathyroidectomy, clusters cells within glands had increased expression. Some COX2-positive exhibited two nuclei, consistent proliferation. Furthermore, nearly 78% expressed proliferating nuclear antigen (PCNA). 5/6-nephrectomy rat model, rats fed a high-phosphate diet significantly higher serum PTH levels and larger than sham-operated rats. Compared controls, uremic more PCNA-positive greater chief cells. Treatment inhibitor celecoxib reduced PCNA expression, attenuated levels, size glands. conclusion, pathogenesis ESRD, suggesting that inhibiting pathway could be potential therapeutic target.