Severe Renal Mass Reduction Impairs Recovery and Promotes Fibrosis after AKI

• DOI: 10.1681/asn.2013040359
• Publication Date: 2014-02-08T07:51:56Z
• Authors: Aaron J. Polichno...; Rongpei Lan; Hui Geng; Karen A. Griffin; Manjeri A. Venkat...; Anil K. Bidani
• Keywords: Male; Organ Size; Acute Kidney Injury; Kidney; Fibrosis; Severity of Illness Index; Rats; Rats, Sprague-Dawley; 03 medical and health sciences; Kidney Tubules; 0302 clinical medicine; Animals

Preexisting CKD may affect the severity of and/or recovery from AKI. We assessed impact prior graded normotensive renal mass reduction on ischemia-reperfusion–induced Rats underwent 40 minutes ischemia 2 weeks after right uninephrectomy and surgical excision both poles left kidney (75% mass), (50% or sham mass. The AKI was comparable among groups, which reflected by similarly increased serum creatinine (SCr; approximately 4.5 mg/dl) at days, tubule necrosis 3 vimentin-expressing regenerating tubules 7 days postischemia-reperfusion. However, SCr remained elevated compared with preischemia-reperfusion values, more failed to differentiate during late 4 ischemia-reperfusion in rats 75% relative other groups. Tubules that continued produce vimentin, exhibited vicarious proliferative signaling, expressed less vascular endothelial growth factor but profibrotic peptides. disproportionate failure redifferentiate associated severe capillary rarefaction greater tubulointerstitial fibrosis. Furthermore, initially developed hypertension proteinuria, 2–4 In summary, (>50%) disproportionately compromised repair, diminished density, promoted fibrosis rats, suggesting accelerated declines function occur patients preexisting CKD.