Short or Long Sleep Duration and CKD: A Mendelian Randomization Study

• DOI: 10.1681/asn.2020050666
• Publication Date: 2020-10-01T19:35:16Z
• Authors: Sehoon Park; Soojin Lee; Yaerim Kim; Yeonhee Lee; Min Woo Kang; Kwangsoo Kim; Yong Chul Kim; Seung Seok Han; Hajeong Lee; Jung Pyo Lee; Kwon Wook Joo; Chun Soo Lim; Yon Su Kim; Dong Ki Kim
• Keywords: Mendelian Randomization

Significance Statement Poor sleep is known to be related kidney function impairment. Using the UK Biobank cohort, including individuals self-reporting regular patterns of short, intermediate, or long duration, authors found that short duration was associated with higher prevalence CKD. In genetic analysis, risk score for but not significantly a CKD stages 3–5, suggesting causal effects on Two-sample Mendelian randomization using independent meta-analysis results from CKDGen Consortium genome-wide association study, also showed significant estimates Clinicians may thus consider encouraging patients avoid short-duration sleeping behavior reduce Background Studies have behaviors, such as and cardiovascular disease risk. However, whether causative factor impairment has been rarely studied. Methods We studied data participants aged 40–69 years in prospective 25,605 (<6 hours per 24 hours), 404,550 reporting intermediate-duration (6–8 35,659 long-duration (≥9 hours) clinical analysis. logistic regression we investigated observational between group prevalent analyzed by performed (MR) analysis involving 321,260 White British instruments (genetic variants linked short- instrumental variables). one-sample MR extended finding two-sample outcome information study meta-analysis. Results Short clinically compared intermediate duration. The (but long) (per unit reflecting two-fold increase odds phenotype; adjusted ratio, 1.80; 95% confidence interval, 1.25 2.60). demonstrated inverse variance weighted method, supported MR-Egger regression. Conclusions These findings support an adverse effect function. encourage