Symptom burden of patients with moderate-to-severe atopic dermatitis

• DOI: 10.1684/ejd.2021.4166
• Publication Date: 2022-02-04T11:52:57Z
• Authors: Alexander Egeberg; Peter Anderson; James Piercy; Lucy Massey; Joseph C. Cappelleri; Gerardo A. Encinas; Claire Feeney; Marco Dibonaventura
• Keywords: Adult; Male; Sleep Wake Disorders; Adolescent; Efficiency; Anxiety; Severity of Illness Index; burden; Dermatitis, Atopic; 03 medical and health sciences; 0302 clinical medicine; Cost of Illness; Absenteeism; Humans; Aged; Aged, 80 and over; atopic dermatitis; Depression; Pruritus; Middle Aged; Health Surveys; 3. Good health; Europe; Quality of Life; health-related quality-of-life; Female

Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with intense and persistent pruritus.To examine associations between AD symptoms and health-related quality of life (HRQoL) in adults (aged ≥18 years) with moderate-to-severe AD.Patient chart and survey data from physicians within Europe were derived from the Adelphi AD Disease Specific Programme (Q3 2019-Q2 2020). HRQoL measures included Euro-Qol 5-dimension, 3-level, questionnaire; Dermatology Life Quality Index; and Work Productivity and Activity Impairment-Atopic Dermatitis questionnaire. Data were evaluated using descriptive statistics and generalized linear models.Of 631 patients, 90.1%, 49.3%, 18.5% and 17.7% reported pruritus, sleep disruption, anxiety and depression, respectively. Adjusted analyses indicated an increased frequency of symptoms associated with worse HRQoL and greater work/activity impairments, particularly for patients with pruritus and sleep disruption.Reductions in symptom frequency may have important implications for improving the overall health of patients with moderate-to-severe AD.