Stevens-Johnson syndrome and toxic epidermal necrolysis: retrospective study of 185 cases in Abidjan (Côte d’Ivoire)

• DOI: 10.1684/mst.2013.0272
• Publication Date: 2019-08-02T13:24:44Z
• Authors: S. Kourouma; A. Sangaré; M. Kaloga; I. Kouassi; E. Ecra; I. Gbery; C. Ahogo; A. Kouassi; K. Kassi; B. Camara
• Keywords: Toxic Epidermal Necrolysis; Cote d ivoire

Cutaneous bullous adverse drug eruptions are a dreaded complication of use. The purpose this study was to document the epidemiological features, outcomes, and causes these reactions, in particular, Stevens-Johnson syndrome toxic epidermal necrolysis (Lyell disease), teaching hospital Abidjan (Côte d'Ivoire). A retrospective reviewed records severe cutaneous reactions patients managed dermatology department University Hospital Treichville (Abidjan) over period ten years (from September 2000 through August 2010). These diseases were diagnosed 185 during period. Their mean age 31.8 (range: 2-70 years) M/F sex ratio 0.6 most frequent as expected, (73%) (27%). drugs commonly involved antibacterial sulfonamides (22.1%), followed by antiviral nevirapine (11.1%), antimalarial agent, sulfadoxine/pyrimethamine. fatality rate 22.5%, including 46% with 14.6% those syndrome. Respiratory distress (39.5%) dehydration (23.4%) primary direct death. Antibacterial leading implicated occurrence Abidjan.