Anti-inflammatory activity of hydrosols from Tetragonia tetragonoides in LPS-induced RAW 264.7 cells.

• DOI: 10.17179/excli2017-121
• Publication Date: 2017-01-01
• Authors: Eun-Yi Ko; Su-Hyeon Cho; Kyungpil Kang; Gibeom Kim; Ji‐Hyeok Lee; You‐Jin Jeon; Daekyung Kim; Ginnae Ahn; Kil‐Nam Kim
• Keywords: Anti-inflammatory

The present study was performed to investigate the anti-inflammatory activity of Tetragonia tetragonoides hydrosols (TTH) and its underlying mechanism in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Gas chromatography (GC) coupled with mass spectrometry retention index calculations showed that TTH were mainly composed tetratetracontane (29.5 %), nonacosane (27.6 oleamide (17.1 %). significantly decreased production nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6, IL-1β LPS-stimulated Consistent these observations, treatment protein expression levels inducible NO synthase (iNOS) cyclooxygenase-2 (COX-2). molecular found be associated inhibition nuclear factor-kappa B (NF-κB) phosphorylation translocation NF-κB 65. Furthermore, markedly suppressed LPS-induced mitogen-activated kinases (MAPKs). Taken together, data indicate exerts an by inhibiting MAPK signaling pathways