Toxic responses of the liver and kidneys following occupational exposure to anesthetic gases.

• DOI: 10.17179/excli2019-1911
• Publication Date: 2020-03-25
• Authors: Masoud Neghab; Fatemeh Amiri; Esmaeel Soleimani; Saeed Yousefinejad; Jafar Hassanzadeh
• Keywords: Gamma-glutamyltransferase; Nephrotoxicity; Liver function

This study was undertaken to determine whether exposure of operating room personnel inhalation anesthetics, including nitrous oxide, isoflurane, and sevoflurane associated with any hepatotoxic or nephrotoxic changes. Fifty-two 52 non-exposed subjects were studied. A questionnaire pertaining demographic characteristics medical history participants completed. Fasting blood samples taken from all measure the functional parameters kidneys liver. Biological monitoring also performed detect urinary concentration IAs. Urinary concentrations found be 175.8 ± 77.52, 4.95 3.43, 15.0 3± 16.06 ppm, respectively. The mean levels alanine aminotransferase, aspartate alkaline phosphatase, gamma-glutamyltransferase, Alpha-glutathione-S-transferase, as well serum kidney injury molecule-1, creatinine calcium significantly higher in exposed group. Statistically significant associations observed between anesthetics creatinine, calcium. Under scenario described present study, occupational subtle, subclinical, pre-pathologic changes liver kidneys. Additionally, Alpha-glutathione-S-transferase molecule-1 sensitive markers for early detection subclinical function who are anesthetics.