Unilateral 6-hydroxydopamine lesion mouse model of Parkinson's disease v1

• DOI: 10.17504/protocols.io.kqdg3q5w1v25/v1
• Publication Date: 2024-12-20T13:16:56Z
• Authors: Cristina Alcacer; Shenyu Zhai
• Keywords: Hydroxydopamine; Oxidopamine

To generate a mouse model of Parkinson's disease, unilateral injection 6-OHDA(6-hydroxydopamine) into the medial forebrain bundle (MFB) was performed. Three to four weeks later, drug-free cylinder test used assess extent lesion.