Quantitative Evaluation of High-Resolution CT Findings in Advanced Cystic Fibrosis Patients Based on the Brody Scoring

• DOI: 10.17795/compreped-4901
• Publication Date: 2015-11-19T13:56:37Z
• Authors: Shahram Kahkouee; Amirali Khodayari...; Mohamad Reza Bolo...
• Keywords: High-resolution computed tomography; Ground-glass opacity; Parenchyma; Honeycombing

Background: Progressive destruction of the lungs leads to increased morbidity and mortality rates in patients with CF. In various studies, it has been shown that quantitative evaluation parenchymal changes lung high-resolution computed tomography (HRCT) CF measured by 2006 revised Brody scoring is compatible clinical status. are mostly children who cannot perform complicated pulmonary tests. Unfortunately, screening tests not performed many countries, such as Iran, resulting late diagnosis older ages, consequently more diffuse involvement hospitalization. The measurement HRCT seems be useful for early accurate Objectives: aim this study was determine severity prevalence diagnosed means system. Patients Methods: Pulmonary results 23 mean age 13.5 years (5 - 18 years) were scored system provided sub-scores evaluating presence five variables central peripheral regions six lobes. Results: All studied had bronchiectasis peribronchial wall thickening (PBWT) which caused disease chronicity. However, form ground glass opacity (GG) consolidation (CON) significantly less prevalent, compared other parameters. highest score among all lobes related lowest (CON, GG). parameters bronchiectasis, PBWT, GG, CON, air trapping showed no significant difference lobar, or involvement, while only mucous plugging prominent zones. contribution lobar appeared following order: right upper lobe (RUL) > left lower (LLL) (RLL) (LUL) Lingula, middle (RML). Conclusions: It advanced cases CF, at ages lack appropriate medical care, severity, prevalence, appearance lesions do follow a definite specific pattern. Therefore, similar suggested larger sample size comparison results.