Chronic hepatitis С and non-alcoholic fatty liver disease. Main aspects of pathogenesis

• DOI: 10.17816/brmma12326
• Publication Date: 2021-07-26T11:28:23Z
• Authors: K V Zhdanov; S S Karyakin; K V Kozlov; D A Gusev; V S Sukachev; A V Saulevich; M V Yaremenko; S N Kizhlo; D M Shahmanov; D Yu Lobzin; M V Kurtukov; M A Dzheriev
• Keywords: 2. Zero hunger; 0303 health sciences; 03 medical and health sciences; 3. Good health

The main pathogenetic aspects of non-alcoholic fatty liver disease as a comorbid factor of chronic hepatitis C are considered. Non-alcoholic fatty liver disease is currently the most common liver disease worldwide, both among adults and children. It is usually accompanied by obesity, insulin resistance and diabetes mellitus. Non-alcoholic fatty liver disease includes a spectrum of pathologies from simple fatty liver infiltration to non-alcoholic steatohepatitis, which is characterized by inflammation with potential progression to fibrosis and cirrhosis over time. On average, non-alcoholic fatty liver disease occurs in 55% of patients with chronic hepatitis C, which is significantly higher than the prevalence of each disease individually. This condition leads to a greater rate of progression of fibrosis, as well as a continuing high risk of developing cirrhosis and hepatocellular carcinoma even after achieving a sustained virological response. In this regard, complex therapy aimed at normalization of the nutritional status, optimization of body weight, correction of impaired intestinal microflora, reduction of severity of liver steatosis and achieving a sustained virological response is a priority task in the treatment of patients with chronic hepatitis C.