Relationship of the myostatin level and secondary sarcopenia in patients undergoing programmed hemodialysis

• DOI: 10.17816/brmma601821
• Publication Date: 2024-01-11T13:27:42Z
• Authors: Vasily N. Tsygan; Olga L. Boriskina; Aleksandr A. Yako...; Alexey P. Tutin
• Keywords: Myostatin

The role of myostatin in the development sarcopenia patients receiving programed hemodialysis and severity relationship with other risk factors, particularly between level blood skeletal muscle indicators, were analyzed. A single-stage prospective non-interventional study was conducted among 196 (97 women 99 men, aged 54–66 years) hemodialysis. After signing informed consent form, all underwent a series examinations consisting assessment anthropometric data, measurement vital signs, determination state muscular system for diagnosis sarcopenia, including bioimpedance, laboratory tests (clinical biochemical tests). serum determined once 10 min before next session. statistically significant negative correlation age (ρ = –0. 361; p 0. 001), strength 140; 05), walking speed 245; 001) observed. High levels more often detected men (U 2633, z –5. 462; 001). positive interleukin-6 found 410; use had sensitivity 71. 4%, specificity cut-off point 5. 01 ng/mL, area under curve 714 (95% confidence interval: 632–0. 795; An increase above ng/mL increases likelihood by 6. 25 times 3. 314–11. 788; χ2 34. 639; chances an threshold value 2,196 according to results short international questionnaire determining physical activity 1. 209–3. 988; 78; 009) higher reduced than normal activity. In general, chronic kidney disease hemodialysis, along level, association interleukin-6, male sex, age, decreased noted, could be used as predictor sarcopenia.