Modern view on the role of pattern-recognition receptors and signaling pathways in the development of innate immunity in viral infections

• DOI: 10.17816/brmma91018
• Publication Date: 2022-07-13T09:56:18Z
• Authors: Alexander V. Mosk...; Boris Yu. Gumile...; Vasiliy Ya. Apchel; Vasiliy N. Tsygan
• Keywords: Immune receptor

Features of organization and functioning pattern-recognizing receptors signaling pathways in induction antiviral immune response are considered. The recognition antigenic structures the virus is carried out by pathogen-associated molecular patterns innate immunity cells. These Toll-like receptors, nucleotide-binding oligomerization domain-like lectin C-type RIG-I-like receptors. these receptor depends on protein molecules that provide activation signals. adapter proteins primary myeloid differentiation 88, interleukin-1 receptor-associated kinase, nuclear factor-KB. Interactions cellular complex receptor-ligand reactions can lead to different outcomes a single cell, most cases leading limitation viral reproduction. An important obstacle effective viruses development an adequate close antigens cell. role LGP2 associated with peculiarities response, which be not only positive, but also negative regulators transmission excitation signals from intracellular cytoplasmic helicase A number inhibit signals, ultimately leads various options for response. special belongs transmembrane endoplasmic reticulum, increases expression interferon stimulator genes detection deoxyribonucleic acid viruses. Maximum this protein, ensures