Clinical and epidemiological characteristics of hepatic cirrhosis of hepatitis C virus etiology in the early stages of its formation

• DOI: 10.17816/eid34792
• Publication Date: 2021-04-07T19:26:53Z
• Authors: Marina G. Avdeeva; Makka I. Kulbuzheva; Antonina А. Ganzha; Olga V. Zapashnaya; Natalia V. Cherni...; Elena I. Kolodko; Lina P. Stolyrova; Husen A. Dobriev; Hassan A. Dobriev
• Keywords: Etiology; Viral Hepatitis; Hepatitis C

Background. Currently, the incidence of viral cirrhosis liver increases significantly, presenting an essential medical and social problem. This study aimed to clarify clinical epidemiological characteristics hepatic hepatitis C virus (HCV) etiology in early stages formation improve quality diagnosis using a sample patients from regional hepatological center Krasnodar (Specialized Clinical Infectious Diseases Hospital).
 Methods. In 2018, 1,307 with diseases were examined treated at center. A retrospective analysis monitoring results 153 HCV replication was performed; mixed excluded study. The enrolled participants included 89 women (58.2%) 64 men (41.8%). average age 53.5 0.93 years. accordance ChildPugh classification cirrhosis, class (I) diagnosed 92 (60.1%) patients, B (II) revealed 53 (34.6%) patients.
 Results. 59.5% cases, damage first detected stage outcome cirrhosis. 1/3 (32.5%) established year visit, another 27%, it during three years date detection markers. less than 1/5 (18.3%) 924 have passed discovery markers establishment During three-year follow-up period, progression transition next occurred 6.5% cases. residents Territory, among leading factors, including monofactor history multifactorial nature almost same frequency, alleged cause infection surgery (43%45%). Prosthetics, dental sanitation, blood transfusion indicated as possible factors high incidence. Factors, such drug addiction, childbirth, tattoos, occupational injuries personnel, abortions, recorded isolated diagnostics compensated increased contents alanine aspartate aminotransferases showed diagnostic value. Mild levels alpha-fetoprotein direct bilirubin, moderate decreases prothrombin index platelets, dilation diameter portal (v. portae) splenic lienalis) veins borderline values upper limit norm size spleen, esophageal varices, development initial encephalopathy also noted. presence extrahepatic manifestations 12% should be considered.
 Conclusion. Despite rate population virus, late often occurred, this finding is partly due action seeking help. On other hand, widespread introduction mandatory examination led active identification sick people. For timely diagnosis, risk for must considered, attention focused on abnormalities biochemical parameters, ultrasound, fibrogastroduodenoscopy data.