Microvascular Endothelium in Patients with Pancreatic Head Cancer and Relationship with Surgical Outcomes

• DOI: 10.17816/onco642394
• Publication Date: 2025-03-05T08:41:21Z
• Authors: Sayakhat T. Olzhaev; Yakov N. Shoykhet; Konstantin S. Titov; Aleksander F. Laz...; Baurzhan J. Adjib...
• Keywords: Pancreatic head

BACKGROUND: The proportion of pancreatic cancer remains high in the overall incidence. Pancreatic ductal adenocarcinoma is a highly aggressive and lethal tumor. AIM: To evaluate microvascular endothelial function patients undergoing head surgery to establish correlation with surgical outcomes. MATERIALS AND METHODS: A prospective observational randomized study was conducted from 2009 2022. included two cohorts: healthy subjects (control group, n=40) diagnosed (patient n=95) who underwent Whipple procedure. assessment functional parameters endothelium measurements circulating cell count, von Willebrand factor (vWF), endothelium-dependent vasodilation. patient group divided into subgroups: main subgroup laparoscopic procedure (n=44) comparison consisted those laparotomy (n=51). In subgroup, were administered combination arginine glutamate (1.0 g daily) enalapril (2.5–5.0mg for treatment dysfunction. RESULTS: sums vWF significantly lower (7.0±1.4 93.6±23.3, respectively), whereas vasodilation higher (9.8±3.2) as compared control (p0.0001). population received dysfunction treatment, 4.2- 4.6-fold reduction levels, respectively, observed (p0.0001 both). Additionally, 4.0-fold increase documented count more than 7.0×104cells/L, 120%, less 10% during period risk early postoperative complications by 2.7, 1.9, 1.7times, respectively incidence non-surgical 28.4 24.2%, respectively. in-hospital mortality rate 5.3%. septic was2.5 3.1times lower, (p0.05). CONCLUSIONS: technique has been shown have protective effect on cancer, reducing complications. baseline vascular demonstrated correlate long-term adverse events, including relapses and/or metastases.