Supplementing traditional drug formulation with the “needed” gases opens the way for the development of a new generation of drugs

• DOI: 10.17816/phbn321616
• Publication Date: 2023-05-11T15:58:36Z
• Authors: Aleksandr L. Urakov; Petr D. Shabanov; Konstantin G. Gur...; Lyubov V. Lovtsova
• Keywords: Mechanism of Action

The mechanism of action drugs is traditionally considered the specific main active ingredients. Therefore, to study drugs, specialists use selected chemical compounds in chemically pure form. However, at beginning 21st century, studies have reported that dosage forms (tablets, solutions, etc.) different from fact tablets, and other contain not only ingredients but also auxiliary, shape-forming ingredients, gases supplement with their nonspecific action. penetrate air; however, can be introduced into under excessive pressure. Evidence presents purposefully altering gas content drug tablets solutions regulate mass, volume, gravity, porosity, physicochemical activity, local pharmacokinetics pharmacodynamics, especially when are administered locally. Examples shown on how this regularity has allowed development a new generation Russia, namely, composition. Studies changing composition old (registered) may turn them drugs. Some invented Russia included formulation, which play role shape-forming, even Thus, was proposed as an additional indicator quality important factor activity. An expanded list hoped for near future.