Virology and histopathology in patients with chronic hbv infection in bulgaria

• DOI: 10.18044/medinform.201853.926
• Publication Date: 2019-03-01T07:36:59Z
• Authors: Donika Krasteva; Radina Ivanova; Cvetelina Marinova; Sonya Dragneva; Nadezhda Zheleva; Evelina Atanasova; Deian Jelev; Krasimir Antonov; Lyudmila Mateva; Zahariy Krastev
• Keywords: Histopathology

The histopathology of hepatitis B is diverse and reflects the natural history chronic HBV-infection.Liver biopsy gold standard for assessment disease-activity fibrosis.Treatment-decision based on liver disease severity as well patient's age, viral load, HBeAg status.The relationship between these parameters not studied in details.We analysed treatment-naïve patients from single canter: 231 with histologically-proven (CHB) 104 subjects clinical, laboratory ultrasound signs cirrhosis (LC).Viral load HBV-serology were measured all cases by real-time PCR ELISA, respectively.Histological biopsies was performed according to METAVIR.Our results showed that number HBeAg-positive patient decreases increase activity A0 A3 fibrosis stage F1 F4.In CHB both inflammation more frequently mild or moderate.Severe (A3) advanced observed HBeAg-negative subjects.HBeAg-positive are younger than HBeAg-negative.Such an age difference exists into separate subgroups