Synthesis, Spectral Correlations and Antimicrobial Activities of 2-Pyrimidine Schiff’s Bases

• DOI: 10.56431/p-4w6n3u
• Publication Date: 2022-12-13T09:50:06Z
• Authors: R. Senbagam; M. Rajarajan; R. Vijayakumar; V. Manikandan; S. Balaji; Ganesan Vanangamudi; G. Thirunarayanan
• Keywords: 01 natural sciences; 0104 chemical sciences

In the present study, a series of substituted (E)-N-benzylidene-2-aminopyrimidine compounds have been synthesized by condensation reaction with 2-aminopyrimidine and meta- and para- substituted benzaldehydes. These synthesized Schiff’s base compounds are confirmed by their physical constants, UV, IR and NMR spectral data. All the observed UV absorption maximum λmax(nm), IR frequencies νC=N(cm-1), NMR δ(ppm) of C-H & C=N chemical shifts have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analyses in order to study the effect of substituents on these spectral data has been studied. The antimicrobial activities of all the synthesized Schiff’s base compounds have been studied using Bauer-Kirby disc diffusion method