Laser-Induced Forward Transfer Printing on Microneedles for Transdermal Delivery of Gemcitabine

• DOI: 10.18063/ijb.v8i2.554
• Publication Date: 2022-05-27T07:45:09Z
• Authors: Zoi Kanaki; Chrysoula Chandrinou; Ioanna-Maria Orfanou; Christina Kryou; Jill Ziesmer; Georgios A. Sotiriou; Apostolos Klinakis; Constantin Tamvak...; Ioanna Zergioti
• Keywords: Transfer printing

Cancer treatment with chemotherapeutic drugs remains to be challenging the physician due limitations associated lack of efficacy or high toxicities. Typically, are administered intravenously, leading drug concentrations that drive but also lead known side effects. Delivery through transdermal microneedles (MNs) has become an important alternative approach. Such delivery options well suited for in which sustained levels would desirable. In context developing a novel approach, laser-induced forward transfer (LIFT) was applied bioprinting gemcitabine (Gem) coat polymethylmethacrylate MNs. Gem, agent used treat various types cancer, is good candidate MN-assisted improve pharmacokinetics Gem while reducing efficiency limitations. LIFT coating MNs different amounts and successful mice presented this study. Our approach produced reproducible, accurate, uniform coatings on MN arrays, vivo application coated mice, dose-proportional plasma achieved. The developed may extended several chemotherapeutics provide advantages metronomic dosing.