Heart failure with preserved left ventricular ejection fraction in patients with obstructive sleep apnea syndrome: prognostic value of biomarkers

• DOI: 10.18087/cardio.2021.11.n1615
• Publication Date: 2021-12-09T14:36:36Z
• Authors: E. V. Grakova; A. V. Yakovlev; S. N. Shilov; E. N. Berezikova; K. V. Kopeva; N. F. Yakovleva; O. N. Ogurkova; A. T. Teplyakov
• Keywords: Brain natriuretic peptide

Aim To study the role of soluble ST2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), and С-reactive protein (CRP) in patients with chronic heart failure preserved left ventricular ejection fraction (CHF pLVEF) syndrome obstructive sleep apnea (SOSA) stratification risk for development cardiovascular complications (CVC) during one month a prospective observation. Material methods The included 71 men SOSA an apnea/hypopnea index (AHI) >15 per hour, abdominal obesity, arterial hypertension. Polysomnographic echocardiography according to standard protocol additional evaluation myocardial fractional changes work were performed all at baseline after 12 months Serum concentrations sST2 , NT-proBNP, CRP measured by enzyme-linked immunoassay (ELISA). Results ROC analysis showed that cutoff point characterizing CVC ≥29.67 ng/l (area under curve, AUC, 0.773, sensitivity 65.71 %, specificity 86.11 %; p<0.0001) while NT-proBNP (AUC 0.619; p=0.081) 0.511; р=0.869) not prognostic markers CVC. According data analysis, divided into 2 groups based on point: group 1 29 42 <29.67 ng/l. Kaplan-Meyer incidence was higher than (79.3 28.6 respectively, p<0.001). regression adding values AHI mass (LVMMI) model increased predictive significance. Conclusion Measuring concentration may be used as noninvasive marker assessment CHF pLVEF within Adding LVMMI increases significance analysis.