Acute impact of a single dose of Dynamine®, TeaCrine, caffeine, and their combination on systemic hemodynamics and associated measures in men and women

• DOI: 10.18103/mra.v8i4.2062
• Publication Date: 2020-04-30T08:44:10Z
• Authors: Richard Bloomer; Matthew Butawan; Jacquelyn Pence
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Background: Dietary supplements purported to improve focus and "energy" often contain stimulants, which elevate both heart rate (HR) blood pressure (BP). We evaluated the safety profile of purine alkaloid methylliberine (Dynamine®) with regards resting HR, BP, respiratory (RR), body temperature (BT). Methods: 6 men (aged: 24±4) women 22±3) ingested (Dynamine®; Compound Solutions, Inc.) at 25mg (M25) 100mg (M100), caffeine 150mg (C150), M100+C150, M100 + theacrine (Teacrine®, 50mg (M100+T50), M100+T50+C150. All conditions were assigned using a Latin square design, approximately one week separating six different assignments. RR, BT collected baseline 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 24, 48 hours post-dose. Subjective mood was also recorded. Meal replacement bars shakes provided after 3 6. Results: For SBP DBP, condition effects noted (p<0.05), all three higher than those without caffeine. Condition for attentive (p=0.02) energetic (p=0.02), M100+C150 greater M100+T50; moody (p<0.01), M100+T50 M100+C150. Main time HR (p<0.001), DBP focused but no statistically significant interactions noted. Conclusion: Methylliberine, alone or in combination and/or theacrine, does not result any increase healthy adults has little impact on subjective mood. These findings should be considered understanding that subjects began testing early morning while fasted rested state two meals (hours 6) during evaluation period, may have impacted