Association Between Vancomycin Blood Brain Barrier Penetration and Clinical Response in Postsurgical Meningitis

• DOI: 10.18433/j3493f
• Publication Date: 2017-07-18T16:59:31Z
• Authors: Qing Wang; Si Chen; Yan-Gang Zhou; Ping Xu; Yi-Ping Liu; Hua-Lin Cai; Hong Chen; Zheng Luo; Hoan Linh Banh
• Keywords: Cmin

This study investigated the association between vancomycin blood brain barrier penetration and clinical response in patients with postsurgical meningitis.Adult meningitis were recruited. Eligible received 500 mg every 6 h for at least 5 days. On day 3 or 4, cerebrospinal fluid (CSF) simultaneous serum samples obtained to determine CSF minimum concentrations (Cmin), Cmin ratio.Twenty-two (14 men 8 women; mean age of 52.6± 12.1 years) The was 3.63 ± 1.64 mg/L 13.38 5.36 serum, ratio 0.291 0.118. showed a significant correlation (p=0.005, r =0.575). had decline white cell counts (WBCs) (p=0.003, =0.609). Cmin, all no (p=0.335, 0.100, 0.679, respectively).There positive Cmin. However, only is positively correlated WBCs improvement CSF. All other parameters such as response. article open POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT issue's contents page.