PHYSICAL AND CHEMICAL PROPERTIES OF BILEDURING THE ONSET AND MANIFESTATION OF CHOLANGITIS. ACUTE CHOLANGITIS: POSSIBLE TRIGGERING MECHANISMS

• DOI: 10.18484/2305-0047.2021.1.20
• Publication Date: 2021-04-08T09:29:43Z
• Authors: V.V. Boyko; A.V. Maloshtan; ; R.M. Smachylo; ; A.A. Nekliudov; ; A.M. Tyshchenko; ; V.A. Vovk; ; M.A. Klosova; ; O.V. Volchenko
• Keywords: Major duodenal papilla; Duodenoscopy

Objective. To determine the possible triggering mechanism for development and manifestation of acute suppurative cholangitis based on study rheological, physical chemical properties bile. Methods. The bile choledoch was studied inpatients (n=41) with calculous obstruction biliary tract, 25 them had clinical picture cholangitis. For comparison, 32 patients asymptomatic choledocholithiasis were examined. Bile sampling performed in each patient twice: first intake obtained during duodenoscopy cannulation major papilla duodenum endoscopic papillosphincterotomy second portion - a follow-up examination three days after papillotomy. pH, viscosity, amount solids it, concentration primary acids, microbial contamination intraductal pressure studied. Results. time, it has been hypothesized that reduced acids causes subsequent chain In is fold decreased comparison control group, case reliable increased but lower than group. It small caused sedimentation colloidal solution, its viscosity dry sediment, precipitation sludge. This process instantaneous inclusion concretion sludge choledoch. As result bacterial contamination, dissemination increases by 10<sup>3</sup>-10<sup>4</sup> times, becomes like an abscess. Endoscopic breaks this surgical management definitive mode treatment decompression track sanitation. Conclusion. A decrease content sedimentation, formation complete block choledoch, which trigger What paper adds Scientific theoretical principles their essencedetermine due to have developed. physicochemical play decisive role Reduction synthesis liver or resorption intestine starts avalanche-like micellar solution stones appears, pH decreases, rises, as infection microbal fold.