Altered Expression of B Cell Receptor Signaling Pathway Genes in Peripheral Blood of Patients with Multiple Sclerosis

• DOI: 10.18502/ijaai.v23i2.15324
• Publication Date: 2024-04-15T07:56:50Z
• Authors: Shirin Jalili; Hadi Shirzad; Seyed Amin Mousav...
• Keywords: Male; Adult; Multiple Sclerosis; Gene Expression Profiling; Receptors, Antigen, B-Cell; Middle Aged; 0302 clinical medicine; Gene Expression Regulation; Case-Control Studies; Humans; Female; Biomarkers; Signal Transduction

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease and has adverse implications. The exact mechanism of its pathogenesis not fully understood remains to be elucidated. In the current study we aimed identify key genes that can serve as potential biomarkers therapeutic targets for MS shed light on mechanisms involved in MS. We analyzed a gene expression dataset (GES21942) found 266 differentially expressed (DEGs) including 183 upregulated 83 downregulated patients compared controls. Then conducted pathway enrichment DEGs selected top enriched i.e., B cell receptor signaling pathway, 5 this (CR2, BLK, BLNK, RASGRP3, KRAS) further investigation our clinical samples. recruited 50 controls assessed circulation versus Expression CR2, RASGRP3 were significantly higher cases with There was no significant difference KRAS between All differential had noticeable diagnostic power CR2 most robust differentiating from Additionally, combination resulted enhanced power. Collectively results suggest may implicated each these considered targets.