Investigating the Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among Patients with Favism Symptoms in Kerman City, Southern Iran

• DOI: 10.18502/ijml.v10i2.12950
• Publication Date: 2023-06-20T07:15:01Z
• Authors: Mohadeseh Kamali; Mehdi Taheri Sarvtin
• Keywords: Primaquine; Glucose-6-Phosphate Dehydrogenase Deficiency; Glucosephosphate Dehydrogenase Deficiency; Cross-sectional study

Background and Aims: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is humans’ most common erythrocyte enzyme defect. About 400 million people are estimated to be affected by this disorder worldwide. Antimalarial drugs, especially primaquine, other oxidative stress, can cause hemolytic complications in G6PD deficient individuals. This study aimed evaluate the prevalence of Kerman City southern Iran. Materials Methods: descriptive cross-sectional was conducted from 2016 2021. Blood samples were taken all patients with symptoms who referred a general hospital The activity measured qualitatively fluorescent spot test. Results: A total 6369 included study. seen 424 (6.7%) subjects. Of patients, 359 (84.7%) severely deficient, 65 (15.3%) exhibited partial deficiency. 324 (9.3%) males 100 (3.4%) females (p < 0.001). Conclusion: results our confirmed existence significant percentage City. Therefore, many city exposed if they use antimalarial drugs substances. According results, testing monitoring potential primaquine toxicity receive highly recommended.