Biofilm and Extended Spectrum Beta Lactamase Production amongst Uropathogenic Escherichia Coli Isolates at the University of Ilorin Teaching Hospital, Nigeria

• DOI: 10.18502/ijml.v6i4.1999
• Publication Date: 2019-12-14T07:12:31Z
• Authors: Dele Ohinoyi Amadu; Charles Nwabuisi; Yahaya Usman; Jelili Olaide Mus...; Idris Nasir Abdul...; Ademola A Popoola
• Keywords: Beta-lactamase

Background and Aims: Uropathogenic Escherichia coli (UPEC) are considered major reservoir for genes encoding antimicrobial resistance. The mechanism of resistance persistence UPEC has been attributed to the production biofilm Extended Beta Lactamase (ESBL). This hospital-based prospective study determined how ESBL facilitate antibacterial amongst isolated from catheter urine patients attending University Ilorin Teaching Hospital, Nigeria. Materials Methods: Urine samples 113 catheterized inpatients outpatients were analysed. Female subjects accounted 47 (41.6%) population. Standard microbiological methods Analytical Profile Index (API) 20E used isolation identification UPEC. Tissue culture plate technique was demonstrate potentials double-disc synergy test determine production. Results: Catheter associated urinary tract infection in this 70.8% Of this, coli, 44 (55.0%) most predominant. UPEC, amounted 38.9%, 81.8% 27.2%, respectively. significantly with degree formation (p<0.005). Both strong moderate producers showed same level ceftazidime (31.6%). Moderate 46.7% resistant cefriaxone. Resistance Amoxillin-clauvanate occurred all grades (p>0.05). Imipenem, however, sensitive no by Conclusions: incidence forming is great public health concern.