Protective Effect of Flaxseed Oil on Diazinon-Induced Cardiotoxicity in Rats in Sub-Chronic Exposure

• DOI: 10.18502/jthc.v19i4.17607
• Publication Date: 2025-01-15T11:24:01Z
• Authors: Akram Ranjbar; Fereshteh Mehri; Maryam Esfahani; Elham Shiri
• Keywords: Malondialdehyde

Background: Diazinon (DZN), an organophosphate insecticide, exerts various adverse effects on human organs. In this study, we investigated the potential cardiotoxic of flaxseed oil (FS oil) oxidative stress caused by DZN in heart tissue rats. Methods: Thirty male rats were divided into five groups: a control group receiving normal saline, FS administered 200 mg/kg/d oil, treated with 70 DZN, and two co-treatment groups alongside at 100 mg/kg/d. We assessed biomarkers tissue, including malondialdehyde, total oxidant status, catalase, superoxide dismutase, thiol content. Heart morphology was analyzed using hematoxylin eosin staining. Results: significantly increased levels malondialdehyde (12.04±1.16) status (0.43±0.01) also decreased content catalase (23.09±1.99), dismutase (5.52±0.61), (6.31±0.77) tissue. FS-oil + (10.88±0.31) (0.41±0.01) (29.34±1.77), (6.64±0.21), (8.20±0.15) supplement consumption reversed dose-dependent manner. Furthermore, ameliorated histopathological alterations induced DZN. Conclusion: Our findings confirmed that toxicity had protective effects. Additionally, supplementation conferred against