Advances and Challenges of Electrospun Nanofibrous Polymer Biomimetic Scaffolds in Cartilage Tissue Engineering

• DOI: 10.18502/ssu.v33i2.18515
• Publication Date: 2025-04-27T08:42:14Z
• Authors: Mehrsa Nasiri; Zahra Ali Asgari; Mohammad Pezeshki...; Milad Jafari Nodo...; Soheila Zamanlui ...; Salar Mohammadi S...
• Keywords: Electrospinning

Introduction: The field of tissue engineering utilizes interdisciplinary sciences such as to repair or regenerate damaged tissues through the integration cellular biology, biomaterials, pharmaceuticals, and signaling molecules reconstruct tissues. Scaffolds, by mimicking natural extracellular matrix (ECM), play a vital role in guiding activities. Cartilage, without blood vessels nerves, lacks ability for self-repair, its injuries are always considered clinical challenge that affects lives millions people incurs significant treatment costs. In recent years, electrospinning technique has gained attention production nanofibers. Electrospun scaffolds, cartilage, provide suitable environment attachment, proliferation, differentiation chondrocytes. use nanofibrous along with cells compatible target tissue, is particular importance cartilage regeneration. Various synthetic polymers have been used regeneration via electrospinning, their effects on nanofiber morphology extensively studied. Conclusion: This review emphasized advancements preparation electrospun scaffolds discussed methods improve performance. It also provides an overview natural, synthetic, composite biomaterials utilized scaffolds. function nanofibers delivering explored. Current challenges this addressed, strategies overcome them, offering potential improvements techniques future application.